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Spirulina did not ameliorate idiopathic chronic fatigue in four N-of-1 randomized controlled trials.

Baicus C, Baicus A

Department of Internal Medicine, Spitalul Colentina, Soseaua Stefan cel Mare 19-21, sect. 2, 020125 Bucharest, Romania. cbaicus@clicknet.ro

Idiopathic chronic fatigue is an exclusion diagnosis established when no chronic disease is found. Spirulina platensis is an alga with a rich content of proteins, vitamins, minerals and amino acids and is considered as a bioactive additive with multiple effects, among them being effects against fatigue. However, despite the worldwide utilization of Spirulina, there are only a few quality studies with it and none concerning fatigue. The N-of-1 randomized trials are made on one patient, and by this kind of study the efficacy of a treatment on that particular patient can be assessed. A series of four N-of-1 double-blind, randomized trials were performed on four physicians who complained of chronic fatigue. Each patient was his own control and received three pairs of treatments comprising 4 weeks of spirulina and 4 weeks of placebo. Spirulina platensis was administered in a dose of 3 g/day. For each pair, the order of treatments was randomized. Outcome measures were severity of fatigue measured on a 10-point scale.The scores of fatigue were not significantly different between spirulina and placebo.Spirulina administered in a dose of 3 g/day did not ameliorate fatigue more than the placebo in any of the four subjects, and possibly it has no effect on chronic fatigue.

Published 22 May 2007 in Phytother Res, 21(6): 570-3.
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